With regard to the first point, although not a TKI sensitivity mutation, the coexisting exon mutation noted in our series may still be a driving mutation.Similarly, within a tissue microarray,coexistence of an ALK gene rearrangement and a classic activating EGFR exon deletion. How frequently potential molecular codrivers exist when larger data sets are available, how cells with more than one driver will react when treated with Spermine specific inhibitors de novo, and whether upregulation or selection of subclones with others drivers could provide a means for acquired resistance following specific inhibitor use, as has, for examp le, been documen tedwi th EGFR mutations and MET gene amplification, remains to be seen. A general trend toward ALK positivity being more common among those with little or no smoking history has been reported. Because EGFR and KRAS mu tationaltesting is becom ing routine ly available, in the absence of universal ALK testing, this prescreening approach could significantly increase the chances of finding these rare patients, enabling treating physicians to determine who it would be most appropriate to refer for ALK screening and possible enrollment within an ALK inhibitor trial.Both age and gender factors have also been reported in association with ALK positivity. However, in the larger data set, taking our own series together with the other U.Here, our median age at diagnosis was similarly low at years, but because the range is so broad, we do not Carvacrol believe that age per se should be used as a preselection criterion for ALK screening for fear of inappropriately excluding patients.Lung cancer is now being divided into several welldefined molecular subtypes. In addition to helping to identify a significant majority of the patients potentially appropriate for treatment with an ALK inhibitor, in the absence of widespread screening of all lung cancer cases for ALK gene rearrangements, the categorical factors we have associated with ALK positivity may a lso prove a use fulfirsts tep toward reexp loring lung cancer epidemiology at the molecular level.By looking in different series of patients preselected by the characteristics we describe here to maximally enrich for patients testing positive, any apparent regional andor national variation in the frequency of ALK positivity may generate hypotheses relating to highrisk genetic andor environmental factorsdiffering between the series to then be explored in more detail in the future.The costs of publication of this article were defrayed in part by the payment of page charges.Tripleplatform testing to predict response to targeted therapy in NSCLC.Clinical features and outcome of patients with nonsmallcelllung cancer who harbor EMLALK. Herbst RS, Heymach JV, Lippman SM.Published OnlineFirst November; DOI. Ross Camidge, Scott A.Access the most recent version of this article at: doi. Click on Request Permissions which will take you to the Copyright Clearance Centers Downloaded from clincancerres.aacrjournals.org on April. American Association for Cancer Research. Intraperitoneal administration of DHMEQ to tumorbearing mice produced a significant amelioration of the reduction in body weight, epididymal fat weight, gastrocnemius muscle weight, hematocrit, and serum levels of triglyceride and albumin when compared with administration of DMSO or no treatment.